Ferose Iron Sucrose

Ferose Iron Sucrose

1. Key Benefits

Ferose Iron Sucrose is a mineral iron replacement product that replenishes body iron stores in patients with iron deficiency anemia, particularly those with chronic kidney disease (CKD). Iron is a mineral that the body needs to produce red blood cells, and when the body does not get enough iron, it cannot produce the number of normal red blood cells needed to maintain good health. The medication provides effective treatment for iron deficiency anemia with proven clinical outcomes and improved quality of life for patients.

2. Indications

Ferose Iron Sucrose is indicated for:

• Treatment of iron-deficiency anemia in people with chronic kidney disease (CKD)
• Iron deficiency anemia in patients who cannot tolerate or do not respond to oral iron therapy
• Iron replacement therapy in patients requiring rapid iron repletion
• Prevention of iron deficiency in high-risk populations
• Treatment of iron deficiency anemia in hemodialysis and peritoneal dialysis patients
• Anemia management in patients with chronic conditions affecting iron absorption

3. How it Works

Iron sucrose is an iron replacement compound that provides elemental iron to the body for red blood cell production. When administered intravenously, iron sucrose releases iron directly into the bloodstream, bypassing gastrointestinal absorption issues that may limit oral iron therapy effectiveness. The iron is then incorporated into hemoglobin synthesis and stored in body tissues, restoring normal iron levels and enabling adequate red blood cell production.

4. Quality and Safety

Manufacturing Standards: Ferose is manufactured by SPIMACO (Al Qassim Pharmaceutical Plant) using pharmaceutical-grade quality control processes ensuring consistent potency and safety.

Safety Profile: Generally well-tolerated when administered according to recommended protocols. Hypersensitivity reactions, including anaphylactic shock, loss of consciousness, collapse, hypotension, dyspnea, and seizure may occur, requiring careful monitoring during administration.

Clinical Monitoring: Monitor iron toxicity through periodic evaluation of laboratory parameters including transferrin saturation, serum ferritin, and complete blood counts to ensure appropriate dosing and prevent iron overload.

5. Important Considerations

Product Formulations:

• Ferose 20mg/ml Drops: Oral formulation for pediatric and adult use
• Ferose Injectable: Intravenous iron sucrose solution for direct administration
• Ferose-F Tablets: Combined iron and folic acid formulation (100mg iron, 0.35mg folic acid)
• Ferose Syrup: 50mg/5ml oral liquid formulation

Dosing Considerations:

• Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses over 14 days (cumulative 1000 mg)
• Peritoneal dialysis-dependent CKD: 300 mg IV infusion for 2 doses 14 days apart, then 400 mg IV infusion 14 days later
• Individual dosing based on patient weight, hemoglobin levels, and iron studies

Contraindications:

• Known hypersensitivity to iron sucrose or any component of the formulation
• History of allergic reaction to iron injections
• Iron overload conditions
• Anemia not associated with iron deficiency

Administration Guidelines:

• Intravenous administration should be performed in healthcare settings with emergency management capabilities
• Administer as slow IV injection or diluted infusion per protocol
• Monitor patients for immediate and delayed hypersensitivity reactions
• Test dose may be considered for high-risk patients

Monitoring Requirements:

• Complete blood count with differential
• Serum iron, total iron-binding capacity, and transferrin saturation
• Serum ferritin levels to assess iron stores
• Liver function tests if indicated
• Vital signs during and after administration

Special Populations:

• Pregnancy: Use only if clearly needed; may harm unborn baby if severe reaction occurs during second or third trimester
• Lactation: Iron is excreted in breast milk; monitor nursing infants
• Elderly: May require dose adjustment based on renal function
• Pediatric: Safety and efficacy established in children ≥2 years old

Professional Note: Ferose Iron Sucrose provides effective iron replacement therapy for patients with iron deficiency anemia, particularly those with chronic kidney disease. Healthcare providers must ensure proper patient selection, monitoring protocols, and emergency preparedness to maximize therapeutic benefits while minimizing risks.

References

1. Iron Sucrose Injection – MedlinePlus Drug Information, National Library of Medicine
2. Venofer (iron sucrose) Dosing and Clinical Guidelines – Medscape Reference
3. Iron Sucrose: Uses, Interactions, Mechanism of Action – DrugBank Online
4. Ferose Product Information – SPIMACO (Al Qassim Pharmaceutical Plant)
5. Iron Sucrose Safety and Administration – Mayo Clinic Drug Information
6. “Efficacy and safety of intravenous iron sucrose in treating adults with iron deficiency anemia” – PMC Scientific Literature